If you are currently being treated with any of the following medications, you
should not use creatine without first talking to your healthcare provider.
Cimetidine, Diuretics, NSAIDs, and Probenecid
Creatine may
increase the likelihood of damage to the kidneys if taken with cimetidine (a
medication for used for heartburn and to prevent ulcers), diuretics, probenecid
(used for gout), or non-steroidal anti-inflammatory (NSAID) medications (such as
ibuprofen).
Other substances
The combined use of caffeine, ephedra (a very
concerning substance frequently found in sports or weight loss supplements), and
creatine has been associated with at least one report of a stroke in a male
weight lifter. It is believed that the combination of creatine with herbs and
medications that stimulate the central nervous system contributed to the stroke.