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| Osteoporosis Medications |
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| Bisphosphonate
Derivatives |
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| Depletions |
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| Calcium |
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Osteoporosis (bone loss) is the primary disease associated with long-term
calcium deficiency; it may be associated with bone pain and spinal deformity.
Depleted levels can also cause muscle cramps, irregular heartbeat, and
depression. |
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| Phosphorus |
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Although phosphorus deficiency is rare, long-term low levels are associated
with muscle weakness, bone pain, mental confusion, loss of appetite, anemia,
increased susceptibility to infection, respiratory difficulties, seizures, and
even death. |
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| Editorial Note |
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| Supporting Research |
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Adami S. Bisphosphonates in prostate carcinoma. Cancer. 1997;80(8
Suppl):1674-1679.
Cashman K, Flynn A. Optimal nutrition: calcium, magnesium and phosphorus.
Proc Nutr Soc. 1999;58:477-487.
Covington T, ed. Nonprescription Drug Therapy Guiding Patient
Self-Care. St Louis, MO: Facts and Comparisons; 1999:467-545.
O'Doherty DP, Gertz BJ, Tindale W, et al. Effects of five daily 1 h infusions
of alendronate on Paget's disease of bone. J Bone Miner Res.
1992;7(1):81-87.
Physicians' Desk Reference. 52nd ed. Montvale, NJ: Medical Economics
Company; 1998.
Potts JT. Diseases of the parathyroid gland and other hyper- and hypocalcemic
disorders. In: Fauci AS, Braunwald E, Isselbacher KJ, et al, eds. Harrison's
Principles of Internal Medicine. 14th ed. New York: McGraw-Hill Companies
Health Professional Division; 1998:2241. |
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| Review Date:
October 2000 |
Reviewed By:
All depletions monographs have been reviewed by a
team of experts including
Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth Amboy, NJ;
Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor, A.D.A.M., Inc., Boston,
MA; John Hinze, PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine Research Institute,
Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy, Clinical Assistant
Professor, University of Maryland School of Pharmacy; President, Your
Prescription for Health, Owings Mills, MD; Leonard Wisneski, MD, FACP, George
Washington University, Rockville, MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu,
HI.
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