Definition:
A goiter is an enlargement of the thyroid gland. It is not cancer. See also:
Alternative Names:
Simple goiter
Causes, incidence, and risk factors:
There are different kinds of goiters. A simple goiter can occur for no known reason, or when the thyroid gland is not able to produce enough thyroid hormone to meet the body's needs. The thyroid gland makes up for this by becoming larger. There are two types of simple goiter: Colloid goiters occur in groups of people who live in areas with iodine-poor soil. These regions are usually away from the sea coast. People in these communities might not get enough iodine in their diet (iodine is needed to produce thyroid hormone). The use of iodized table salt in the United States today prevents iodine deficiency. However, the Great Lakes, Midwest, and innermountain areas of the United States were once called the "goiter belt," because a high number of goiter cases occured there. A lack of enough iodine is still common in central Asia, the Andes region of South America, and central Africa. For more information on this type of goiter, see: Colloid nodule goiter. In most cases of sporadic goiter the cause is unknown. Occasionally, certain medications such as lithium or aminoglutethimide can cause a nontoxic goiter. Inherited factors may cause goiters. Risk factors include:
References:
Vanderpas J. Nutritional epidemiology and thyroid hormone metabolism. Ann Rev Nutr. 2006; 26:293-322. AACE/AME. American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi. Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules. Endocr Pract. 2006 Jan-Feb;12(1):63-102. Ladenson P, Kim M. Thyroid. In: Goldman L and Ausiello D, eds. Goldman: Cecil Medicine. 23rd ed. Philadelphia, Pa:Saunders; 2007:chap 244.
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