Definition:
Cervical cancer is cancer that starts in the cervix, the lower part of the uterus (womb) that opens at the top of the vagina.
Alternative Names:
Cancer - cervix
Causes, incidence, and risk factors:
Worldwide, cervical cancer is the third most common type of cancer in women. It is much less common in the United States because of routine use of Pap smears. Cervical cancers start in the cells on the surface of the cervix. There are two types of cells on the cervix's surface: squamous and columnar. The majority of cervical cancers are from squamous cells. The development of cervical cancer is usually very slow. It starts as a pre-cancerous condition called dysplasia. This pre-cancerous condition can be detected by a Pap smear and is 100% treatable. That is why it is so important for women to get regular Pap smears. Most women that are diagnosed with cervical cancer today have not had regular Pap smears or they have not followed up on abnormal results. Undetected, pre-cancerous changes can develop into cervical cancer and spread to the bladder, intestines, lungs, and liver. It can take years for pre-cancerous changes to turn into cervical cancer. Patients with cervical cancer do not usually have problems until the cancer is advanced and has spread. Almost all cervical cancers are caused by HPV (human papilloma virus). HPV is a common virus that is spread through sexual intercourse. There are many different types of HPV, and many do not cause problems. However, only certain strains of HPV actually lead to cervical cancer. (Other strains may cause genital warts.) Other risk factors for cervical cancer include: - Having sex at an early age
- Multiple sexual partners
- Sexual partners who have multiple partners or who participate in high-risk sexual activities
- Women whose mothers took the drug DES (diethylstilbestrol) during pregnancy in the early 1960s to prevent miscarriage
- Weakened immune system
- Poor economic status (may not be able to afford regular Pap smears)
References:
Armstrong C. ACIP Releases Recommendations on Quadrivalent Human Papillomavirus Vaccine. Am Fam Physician. May 1, 2007;75(9);1391-1380. Diaz ML. Human Papilloma Virus - Prevention and Treatment. Obstet Gynecol Clin North Am. June 2008;35(2);199-217. NCCN Clinical Practical Guidelines in Oncology: Cervical cancer. 1st ed. 2008. Accessed June 10, 2008.
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